(-)-pluviatolide 4-O-methyltransferase (EC 2.1.1.323)
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(-)-pluviatolide 4-O-methyltransferase
EC Number: 2.1.1.323
Reaction: S-adenosyl-L-methionine + (-)-pluviatolide = S-adenosyl-L-homocysteine + (-)-bursehernin
Systematic name: S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase
Other names: OMT3 (gene name)
Comments: The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.