biflaviolin synthase (EC 1.14.21.7)
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biflaviolin synthase
EC Number: 1.14.21.7
Reaction: (1) 2 flaviolin + NADPH + H+ + O2 = 3,3'-biflaviolin + NADP+ + 2 H2O;;(2) 2 flaviolin + NADPH + H+ + O2 = 3,8'-biflaviolin + NADP+ + 2 H2O
Systematic name: flaviolin,NADPH:oxygen oxidoreductase
Other names: CYP158A2; CYP 158A2; cytochrome P450 158A2
Comments: This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1].