ribitol-5-phosphate 2-dehydrogenase (NADP+) (EC 1.1.1.405)
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ribitol-5-phosphate 2-dehydrogenase (NADP+)
EC Number: 1.1.1.405
Reaction: D-ribitol 5-phosphate + NADP+ = D-ribulose 5-phosphate + NADPH + H+
Systematic name: D-ribitol-5-phosphate:NADP+ 2-oxidoreductase
Other names: acs1 (gene name); bcs1 (gene name); tarJ (gene name); ribulose-5-phosphate reductase; ribulose-5-P reductase; D-ribulose 5-phosphate reductase
Comments: Requires Zn2+. The enzyme, characterized in bacteria, is specific for NADP. It is part of the synthesis pathway of CDP-ribitol. In Haemophilus influenzae it is part of a multifunctional enzyme also catalysing EC 2.7.7.40, D-ribitol-5-phosphate cytidylyltransferase. cf. EC 1.1.1.137, ribitol-5-phosphate 2-dehydrogenase.