VOLUME 526. Hydrogen Peroxide and Cell Signaling, Part A

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"The identification of hydrogen peroxide in regulation of cell signaling and gene expression was a significant breakthrough in oxygen biology. Hydrogen peroxide is probably the most important redox signaling molecule that, among others, can activate NFkB, Nrf2, and other universal transcription factors and is involved in the regulation of insulin and MAPK signaling. These pleiotropic effects of hydrogen peroxide are largely accounted for by changes in the thiol/disulfide status of the cell, an important determinant of the cell’s redox status. Moreover, disruption of redox signaling and control recognizes the occurrence of compartmentalized cell redox circuits." "Hydrogen peroxide signaling has been of central importance in cell research for some time, and some previous volumes of Methods in Enzymology have covered in part some aspects of the physiological roles of hydrogen peroxide. However, there have been new developments and techniques that warrant these three volumes of Methods in Enzymology, which were designed to be the premier place for a compendium of hydrogen peroxide detection and delivery methods, microdomain imaging, and determinants of hydrogen peroxide steady-state levels; in addition, the role of hydrogen peroxide in cellular processes entailing redox regulation of cell signaling and transcription was covered by experts in mammalian and plant biochemistry and physiology."