Base Excision Repair

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Overview

First, a glycolyase cuts the damaged base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. The strand is then sealed with DNA ligase.

Overview Figure

Details