Base Excision Repair: Difference between revisions
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Created page with "First, a glycolyase cuts the base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or A..." |
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First, a glycolyase cuts the base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. | ==Overview== | ||
First, a glycolyase cuts the damaged base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. The strand is then sealed with DNA ligase. | |||
==Overview Figure== | |||
==Details== | |||
Latest revision as of 20:44, 9 September 2021
Overview
First, a glycolyase cuts the damaged base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. The strand is then sealed with DNA ligase.