Difference between revisions of "Base Excision Repair"
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| + | ==Overview== | ||
First, a glycolyase cuts the damaged base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. The strand is then sealed with DNA ligase. | First, a glycolyase cuts the damaged base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. The strand is then sealed with DNA ligase. | ||
| + | ==Overview Figure== | ||
| + | ==Dteails== | ||
Revision as of 20:44, 9 September 2021
Overview
First, a glycolyase cuts the damaged base off of its sugar. The site is now referred to as an AP site (apurinic/apyrimidinic). This AP site is then recognized and cut by AP lyase or AP endonuclease, creating a single-stranded break. A polymerase then adds a new nucleotide using the opposite strand as a template. The strand is then sealed with DNA ligase.
